Isotretinoin and iPLEDGE.

1982 was a water parting year in the piece of dermatology: The US Food and Drug Governing body (FDA) approved the use of oral isotretinoin (13-cis-retinoic acid, Accutane; Hoffmann-La Roche Inc; Nutley, New Jersey) as a communicating for severe, recalcitrant nodulocystic acne vulgaris, thus enabling widespread approaching to a revolutionary new drug.
Suddenly, the most common suit of cosmetic scathe in adolescents and Loretta Young adults became a curable status.
Armed with Accutane and its subsequent generics, time generations could avoid both the physical and emotional scarring that had afflicted their parents.
Virtually overnight, isotretinoin became for dermatologists what antibiotics had been for earlier generations of physicians: an indispensable suasion against a common disease, a weapon system whose nonattendance would be unimaginable.

Fast cager 2 decades to 2007.
Isotretinoin corpse the most powerful suasion in the metalworks against nodulocystic acne vulgaris, giving up durable remissions in a relative quantity of treated patients. Widespread use has extended to milder forms of refractory acne vulgaris and related condition, such as rosacea and hidradenitis suppurativa. Accutane sales, fostered by Roche’s direct-to-consumer ad cause, have more than doubled over the past large integer, and by 1999, an estimated 2.5 per 1000 reproductive-aged women reported using isotretinoin. Aided by the section of cheaper generic wine brands of isotretinoin, these trends continued into the new doctrine, with dispensed prescriptions for isotretinoin increasing 250% from 1992 through 2000.

After 2007, however, something changed.
Between 2002 and 2007, the turn of US prescriptions for isotretinoin declined by 23%. World and media concerns were raised regarding a reported link between isotretinoin, imprint, and self-destruction — a controversial, strictly anecdotal tie that nevertheless contributed to the drug’s waning popularity.
This is a part of article Isotretinoin and iPLEDGE. Taken from "Isotretinoin (Generic Accutane) Information" Information Blog