Isotretinoin and Pregnancy - A Continued Risk for Birth Defects. Part 1

In September 2007, the US Food and Drug Term of office (FDA) approved the drug isotretinoin (Accutane) for use in the handling of severe recalcitrant nodular acne. Accutane,
taken orally over 20 weeks, was shown to be highly effective in
treating this serious form of acne.
However, within a year and a half of its subject matter, 29 cases of
“adverse reproductive outcomes among women taking isotretinoin during
the number 1 academic term of pregnancy” were reported in the State of mind and Mortality rate Weekly Informing
(MMWR). Of the 34 exposed women reported, 19 experienced spontaneous
stillbirth, and 10 babies were born with congenital malformations now
understood to be the fetal isotretinoin symptom.

Smith’s Recognizable Patterns of Human Affliction
reports that retinoic acid embryopathy, also known as Accutane
embryopathy or fetal isotretinoin complex, consists of a set of
malformations involving the central nervous structure, head and face,
and meat.
Isotretinoin (13-cis-retinoic acid) is a synthetic retinoid or vitamin
A legal instrument.
The retinoids are involved in the HOX signaling pathways that are used
to ornament the branchial arches (pharyngeal arches) during the common
fraction week of embryonic processing.
It is not surprising, therefore, that the derivatives of the pharyngeal
arches are affected by isotretinoin picture during pregnancy, namely
the central nervous structure (CNS), craniofacial features, and cardiac
structures.

Children
with the isotretinoin symptom often demonstrate cranial nerve
asymmetry; serious external ear abnormalities, including microtia
(small ear), anotia (no ear), or stenosis of the external ear canal;
micrognathia (small jaw); flat depressed nasal bone bridge; and ocular
hypertelorism (widely spaced eyes).
The cardiovascular abnormalities commonly seen include conotruncal
malformations, such as genetic mutation of the great vessels and
tetralogy of Fallot.
Effects on the CNS can lead to hydrocephalus and microcephaly as well
as to an IQ in the subnormal miscellanea and erudition disabilities.
Thymic aplasia and parathyroid abnormalities can also be part of this
complex.

This is a part of article Isotretinoin and Pregnancy - A Continued Risk for Birth Defects. Part 1 Taken from "Isotretinoin (Generic Accutane) Information" Information Blog